Genome Stability: A Self-Sufficient DNA Repair Machine
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چکیده
منابع مشابه
Genome Stability: A Self-Sufficient DNA Repair Machine
The repair of DNA double-strand breaks often requires the broken ends to be processed prior to religation. New results describe a bacterial enzyme with processing and rejoining activities encoded in a single polypeptide chain.
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Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability...
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Gene Control, second edition, is a concise book that focuses on gene expression and regulation in eukaryotes. Synonymous with the first edition, the chapters build on themselves, culminating in a discussion correlating gene control in regard to human health and disease. The author uses illustrations where appropriate, focusing on simplistic figures that correlate DNA, RNA, and regulatory protei...
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Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent dat...
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Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Repair by homologous recombination is generally accurate as it uses undamaged homologous DNA molecule as a repair template. In Escherichia coli homologous recombination repairs both the double-strand breaks and single-strand gaps in DNA. DNA double-strand breaks (DSB) can be induced upon exposure to...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2005
ISSN: 0960-9822
DOI: 10.1016/j.cub.2004.12.014